Introduction. Download a PDF version. Atrial fibrillation (AF) is frequently associated with HCM with a reported prevalence of about 20% to 25%. Maron BJ, Bonow RO, Cannon RO, et al. It's FREE! In 2010, the Study Group on peripartum cardiomyopathy of the Heart Failure Association (HFA) of the European Society of Cardiology (ESC) defined PPCM as an idiopathic cardiomyopathy occurring towards the end of pregnancy or in the months following delivery, abortion or miscarriage, without other causes for heart failure, and with a left ventricular (LV) ejection fraction (EF) < 45% 5 (see Box). Clipping is a handy way to collect important slides you want to go back to later. Hypertrophic cardiomyopathy (HCM) is the most common monogenic cardiovascular disorder, affecting one of every 500 adults.It is found across all racial groups and is the most common cause of sudden death in young athletes ().The disease is characterized by left ventricular (LV) hypertrophy in the absence of another systemic or cardiac disease to account for the changes noted. Classification and Definitions of Cardiomyopathies 9 3.1. The parts of the heart most commonly affected are the interventricular septum and the ventricles. 22: Figure 1. Long-term Hypertension B. Aortic Stenosis C. Myocardial Ischemia D. Familial and Genetic, Hypertrophic Cardiomyopathy (HCM) Therapeutics Market Analysis by Demand, Trend, Revenue, Market Segment & Forecast to 2023. - Cardiomyopathy is a serious condition of the heart, in which the heart muscles become inflamed and weakened. Hypertrophic cardiomyopathy (HCM) is a disorder of the myocardium caused by mutations of the sarcomere or sarcomere-associated proteins. - Famous for being leading cause of sudden cardiac death in young athletes ... Enlarged septum narrows left ventricle outflow tract. At the present stage of development of our knowledge, enough data has accumulated, suggesting that hypertrophic cardiomyopathy is a hereditary disease transmitted by an autosomal dominant type with various penetrance and expressiveness. Hypertrophic cardiomyopathy (HCM) is the most common monogenic cardiovascular disorder, affecting one of every 500 adults.It is found across all racial groups and is the most common cause of sudden death in young athletes ().The disease is characterized by left ventricular (LV) hypertrophy in the absence of another systemic or cardiac disease to account for the changes noted. That's all free as well! Cardiomyopathies are diseases of the muscle tissue of the heart.Types of cardiomyopathies include dilated, hypertrophic, restrictive, and arrhythmogenic right ventricular cardiomyopathy. Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. They are all artistically enhanced with visually stunning color, shadow and lighting effects. The Global Therapeutic Landscape of Hypertrophic Cardiomyopathy. DISCUSSION: Hypertrophic cardiomyopathy(HCM) is a condition of the heart characterized by the thickening of the interventricular septum. Case17 years old male professional basketball player with noknown past medical history collapses on the playing floorduring practice and subsequently arrests. Takotsubotype cardiomyopathy due to multivesselspasm. Hypertrophic Cardiomyopathy ; various degree of hypertrophy ; various degree of obstruction ; various age at presentation ; various mortality risk; 15 Hypertrophic Cardiomyopathy. Hypertrophic cardiomyopathy (HCM) is a common genetic cardiac disorder, with an autosomal dominant mechanism of inheritance. HCM can run in families, but the condition may also be acquired as a part of aging or high blood pressure. Cardiomyopathies are diseases of the muscle tissue of the heart.Types of cardiomyopathies include dilated, hypertrophic, restrictive, and arrhythmogenic right ventricular cardiomyopathy. The global Hypertrophic Cardiomyopathy (HCM) Therapeutics market explains the Hypertrophic Cardiomyopathy (HCM) Therapeutics market development trends, market size and large-scale industry situation to provide progressive approximation. Caused by blockages in coronary arteries ... Mimics myocardial infarction ... Alpha and beta blockers the best treatment. Atrial fibrillation (AF) is frequently associated with HCM with a reported prevalence of about 20% to 25%. 2,3 Recognised autosomal dominant mutations within sarcomere proteins are found in 55 % of adolescents with sporadic HCM. - ... Hypertrophy: in any region of left ventricle SAM: systolic anterior motion of anterior MV leaflet against hypertrophic septum (Bernoulli effect) ... - Cardiomyopathy Dr.mirdamadi Cardiologist, fellowship of echocardiograpy Apical HCM Apical hypertrophy Giant negative T wave on the ECG Spade shaped LV cavity ... - Dilated cardiomyopathy or DCM is a condition in which the heart becomes weakened and enlarged and cannot pump blood efficiently. Powerpoint slides. Introduction. Circulation. TM, 54, WAS ADMITTED to the ED after a syncopal episode that resulted in a head injury. CrystalGraphics 3D Character Slides for PowerPoint, - CrystalGraphics 3D Character Slides for PowerPoint. It is occasionally restricted to other myocardial regions, such as the apex, the midportion, and the posterior wall of the left ventricle… - Beautifully designed chart and diagram s for PowerPoint with visually stunning graphics and animation effects. 14. INTRODUCTION. Hypertrophic Cardiomyopathy Dr. Fuad Farooq Resident CardiologyAga Khan University Hospital. MAIN TYPES OF CARDIOMYOPATHY Hypertrophic Cardiomyopathy: Hypertrophy means ‘increase in size.’ It is the increase in size of the heart muscle. Circulation. Heart 2010; 96(20):1669-75 [8] Richard P, Charron P, ... | PowerPoint PPT presentation | free to view, Global Hypertrophic Cardiomyopathy (HCM) Therapeutics Market Insight and Forecast to 2026. ... Cardiomyopathy Pathophysiology. the diagnosis, characterize the pathophysiology for the individual, and identify risk markers that may inform decisions regarding interventions ... *HCM indicates hypertrophic cardiomyopathy . The ... Development of a New Method to Prioritise Gene Analysis in Familial Hypertrophic Cardiomyopathy, - Development of a New Method to Prioritise Gene Analysis in Familial Hypertrophic Cardiomyopathy Jayne Duncan West of Scotland Regional Genetics Service, Glasgow, - Hypertrophic Obstructive Cardiomyopathy (Case Presentation) Ashraf Andrawis, MD Norman Bolden, MD Metrohealth medical center- CWRU Department of anesthesiology. However, in a small number of people wi… Aetiology. Hypertrophic cardiomyopathy. D. Aortic stenosis. Hypertrophic cardiomyopathy (HCM) (see the image below) is a genetic disorder that is typically inherited in an autosomal dominant fashion with variable penetrance and variable expressivity. The parts of the heart most commonly affected are the interventricular septum and the ventricles. A J Marian (Jan 1, p 58)1 postulates that cardiac contractility is decreased in hypertrophic cardiomyopathy (HCM) and that the preserved or increased ejection fraction observed in patients with HCM is a result of the concentric nature of the hypertrophy. 1996;94:850-56. Hypertrophic Non-Obstructive Cardiomyopathy (HNCM) is a subtype of hypertrophic cardiomyopathy, which is a condition affecting the heart muscle The term “hypertrophic” means enlargement of cells, which, in this condition, leads to a thickening of the heart muscle. Sudden cardiac death due to HCM-related causes is most prevalent in young African-American male athletes. When this happens, the ventricle has to work harder to pump out blood. Hypertrophic cardiomyopathy (HCM) is defined as a primary cardiac muscle hypertrophy of the left ventricle in the absence of other structural or functional abnormality. ... An 80-year-old African-American woman is admitted to the hospital under your ... - Hypertrophic Cardiomyopathy Board Review Rami Khouzam, MD ... Congestive dilated cardiomyopathy. PowerShow.com is a leading presentation/slideshow sharing website. This scarring leads to progressive thinning of the septum  outflow tract enlargement (mimicking LV remodeling that occurs after myectomy). It was first brought to attention by the British forensic pathologist Donald Teare in 1958 as a disease manifesting with symmetric or asymmetric left ventricular hypertrophy (LVH) > 1.5 cm (Figure 23–1) in a nondilated ventricle. Questions? 16. 1. Alcohol septal ablation. It mainly manifests as symmetric or asymmetric left ventricular hypertrophy (LVH) > 1.5 cm (Figure 23–1) in a nondilated ventricle unexplained by other cardiac or systemic causes of hypertrophy (see Table 23–1 for differential diagnosis of LVH). - Hypertrophic cardiomyopathy Frank and Mehta Non-Surgical Septal Ablation Echocardiographic still frames (systole) from the parasternal long-axis. Luis Fuentes V, Wilkie L J (2017) Asymptomative hypertrophic cardiomyopathy: Diagnosis and therapy. The two patients thought to be in cardiogenic shock were given inotropes … In: Kodama K, Haze, K, Hon M, editors. - Hypertrophic Cardiomyopathy (HCM) Therapeutics market report provides a brief and detailed knowledge of key reports, market conditions and circumstances. Powerpoint slides. Cardiomyopathy: Pathophysiology and Assessment RobertoMLang,MD Circ J 2004; 68: 77-81 Japanese word for octopus catcher Tako-Tsubo Cardiomyopathy Broken Heart Syndrome Apical Balooning 1. The disease has complex symptomatology and potentially devastating consequences for … The Global Therapeutic Landscape of Hypertrophic Cardiomyopathy - The report provides comprehensive information on the therapeutics under development for Hypertrophic Cardiomyopathy, complete with analysis by stage of development, drug target, mechanism of action (MoA), route of administration (RoA) and molecule type. - Myocyte 'disarray' 2/2 sarcomere mutations causes LV hypertrophy, usually with ... hypertrophic subaortic stenosis) and ASH (Asymmetric septal hypertrophy) are ... - Hypertrophic Cardiomyopathy Board Review Rami Khouzam, MD Hypertrophic Cardiomyopathy Definition: WHO: left and/or right ventricular hypertrophy, usually asymmetric ... Heart Muscle Disease (Cardiomyopathy) (1). Hypertrophic cardiomyopathy Characterised by myocardial hypertrophy,abnormal diastolic filling,intermittent ventricular outflow obstruction Related to defects in force generation owing to altered sarcomeric function Leading cause of LVH,unexplained by other clinical/pathologic cause Caused by mutation of genes encoding sarcomeric proteins Aetiology. Change in stress leads to adaptations. Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiovascular disorder, representing a leading cause of sudden cardiac death in the young and a prevalent cause of heart failure and stroke. Hypertrophic cardiomyopathy (HCM) is a disorder of the myocardium caused by mutations of the sarcomere or sarcomere-associated proteins. Whether your application is business, how-to, education, medicine, school, church, sales, marketing, online training or just for fun, PowerShow.com is a great resource. Hypertrophic cardiomyopathy (HCM) is a primary and usually familial cardiac disorder with heterogeneous expression, unique pathophysiology, and a diverse clinical course, for which several disease-causing mutations in genes encoding proteins of the sarcomere have been reported.1–7 Because of the characteristic clinical, morphological, and genetic diversity, HCM has held the curiosity … You can change your ad preferences anytime. Circulation. Hypertrophic cardiomyopathy (HCM) is a disorder of the myocardium caused by mutations of the sarcomere or sarcomere-associated proteins. Cardiomyopathy Medication Market-Global Forecast to 2025. Through a distal port on the balloon-tipped catheter,1-3 mL of ethanol is injected into the septal artery resulting in a controlled myocardial infarction. Hypertrophic cardiomyopathy (HCM) is a heterogeneous genetic heart muscle disease affecting 1 of every 500 persons (1, 2).Individuals with HCM are at an increased risk of heart failure and sudden cardiac death ().Usually, HCM is characterized by cardiac hypertrophy with preserved or increased ejection fraction (EF) and cardiac contractility in the absence of secondary causes. Images. - The report provides comprehensive information on the therapeutics under development for Hypertrophic Cardiomyopathy, complete with analysis by stage of development, drug target, mechanism of action (MoA), route of administration (RoA) and molecule type. Causes of sudden cardiac death in young people Myocarditis 3% Maron BJ et al. The septal artery catheter balloon is inflated preventing backwash of alcohol into the remainder of the coronary tree. Hypertrophic cardiomyopathy (HCM) is an intractable disease that causes heart failure mainly due to unexplained severe cardiac hypertrophy and diastolic dysfunction. If you continue browsing the site, you agree to the use of cookies on this website. Hypertrophic cardiomyopathy 1. 22: Figure 1. Circulation. Etiology of Hypertrophic Cardiomyopathy is mostly due to: A. the diagnosis, characterize the pathophysiology for the individual, and identify risk markers that may inform decisions regarding interventions ... *HCM indicates hypertrophic cardiomyopathy . Introduction. 1 It is typically inherited via autosomal dominant pattern with mutations in cardiac sarcomere protein genes. Etiology of Hypertrophic Cardiomyopathy is mostly due to: - 1. Evaluation and Testing for HCM. In the early stages of cardiomyopathy, there may be no symptoms at all. HCM can run in families, but the condition may also be acquired as a part of aging or high blood pressure. Boasting an impressive range of designs, they will support your presentations with inspiring background photos or videos that support your themes, set the right mood, enhance your credibility and inspire your audiences. Hypertrophic cardiomyopathy is a primarily genetic condition affecting the sarcomeric proteins. - ... Day S, Rehm HL, Baxter S. Use and interpretation of genetic tests in cardiovascular genetics. - Cardiomyopathy (literally "heart muscle disease") is the measurable deterioration of the function of the myocardium (the heart muscle) for any reason usually leading to heart failure. N Engl J Med 1997336775-785. Change in stress leads to adaptations. This results in the heart being less able to pump blood effectively and also may cause electrical conduction problems.. People who have HCM may have a range of symptoms. Hypertrophic cardiomyopathy (HCM) is a primary and usually familial cardiac disorder with heterogeneous expression, unique pathophysiology, and a diverse clinical course, for which several disease-causing mutations in genes encoding proteins of the sarcomere have been reported.1–7 Because of the characteristic clinical, morphological, and genetic diversity, HCM has held the curiosity … Complete heart block: 30-40% in early studies, now <10% using smaller doses of alcohol more selectively Large MIs: from alcohol leakage into other coronary arteries, Non-randomized study – aim to determine outcomes in a tertiary referral center Of 601 patients referred between 1998-2006, 138 chose alcohol septal ablation Median age 64 yo Fewer procedural complications in patients w/ myectomy: combined post-procedural complication rate 26% in ablation vs. 5% in myectomy 2 deaths – 1 patient transferred from OSH w/ cardiogenic shock, 1 patient w/ pulmonary HTN Overall survival: 93.5% at 2 yrs, 88% at 4 yrs, Initial registry study in 2000 looking at the efficacy of ICDs for the prevention of SCD in HCM patients Retrospective multicenter study of 19 centers in US and Italy 128 consecutive patients enrolled; ICDs placed between 1984-1998 85 pts = primary prevention 43 pts = secondary prevention. HCM is an inherited (autosomal dominant) disease of the myocardium. Hypertrophic cardiomyopathy (HCM) is defined as a primary cardiac muscle hypertrophy of the left ventricle in the absence of other structural or functional abnormality. Initial clinical and hemodynamic evaluation suggested cardiogenic shock in two cases, acute myocardial ischemia in two cases, and hypovolemia in one case. The main pathophysiology behind is that every organ is in homeostasis with physiological stress. Cardiology Grand Rounds from the University of Texas Medical Branch Hypertrophic Cardiomyopathy: Presentation and Pathophysiology Marschall S. Runge, MD George A. Stouffer, MD * Richard G. Sheahan, MD Stamatios Lerakis, MD From the Division of Cardiology, Department of Medicine, The University of Texas Medical Branch, Galveston, Texas. Images. Hypertrophic Cardiomyopathy Dr. Fuad Farooq Resident CardiologyAga Khan University Hospital 2. See our User Agreement and Privacy Policy. Hypertrophic cardiomyopathy (HCM) is a disease in which the heart muscle (myocardium) becomes abnormally thick (hypertrophied). Cardiomyopathy is any structural and functional abnormality of the heart muscle unattributable to specific causes or disease processes such as coronary artery disease (CAD), congenital heart disease, or valvular disease. Evaluation and Testing for HCM. Hypertrophic cardiomyopathy (HCM) (see the image below) is a genetic disorder that is typically inherited in an autosomal dominant fashion with variable penetrance and variable expressivity. The report also covers the descriptive pharmacological action … Cardiomyopathy: Pathophysiology and Assessment RobertoMLang,MD Circ J 2004; 68: 77-81 Japanese word for octopus catcher Tako-Tsubo Cardiomyopathy Broken Heart Syndrome Apical Balooning 1. And, best of all, most of its cool features are free and easy to use. Hypertrophic cardiomyopathy (HCM) is a condition in which the heart becomes thickened without an obvious cause. Five patients, all women, age ranges 59 to 84 years, with underlying hypertrophic obstructive cardiomyopathy (HOCM) presented with profound hypotension. CARDIOMYOPATHY BY: RICHARD KAMINSKI DESCRIPTION OF DISEASE • Hypertrophic cardiomyopathy (HCM) occurs if heart muscle cells enlarge and cause the walls of the ventricles (usually the left ventricle) to thicken. Five patients, all women, age ranges 59 to 84 years, with underlying hypertrophic obstructive cardiomyopathy (HOCM) presented with profound hypotension. Dilated cardiomyopathy is the most common type of cardiomyopathy.Although most cases are idiopathic, a number of conditions (e.g., coronary artery disease, wet beriberi), infections … N Engl J Med 1997336775-785 gt 140. Hypertrophic cardiomyopathy (HCM) is a genetic disorder of cardiac myocytes that is characterized by cardiac hypertrophy, unexplained by the loading conditions; a nondilated left ventricle; and a normal or increased ejection fraction. N Engl J Med. Initial clinical and hemodynamic evaluation suggested cardiogenic shock in two cases, acute myocardial ischemia in two cases, and hypovolemia in one case. Increased voltages c/w left ventricular hypertrophy Repolarization changes Q waves = not ischemia – reflect anterior septal thickness, Decreased projection of basal septum into the LVOT, Gold standard for pts w/ drug-refractory HCM Resect a small portion of myocardium from septum – enlarges LVOT and relieves obstruction; also causes concomitant mitral regurg to disappear Operative mortality: <1% Complications rare (heart block, VSD, aortic regurg). Clinical aspect of myocardial XXX:XX-XX. - Title: PowerPoint Presentation Author: Scott Johnson Last modified by: Authorised User Created Date: 3/10/2009 8:02:56 PM Document presentation format, Cardiomyopathy : Causes, Symptoms,Types, Diagnosis and Treatment (1). Genetic Etiology of Hypertrophic Cardiomyopathy (HCM) ~30-60% of HCM patients have an identifiable pathogenic or likely-pathogenic genetic variant Many others have no genetic evidence of disease and / or HCM, which occurs in 0.2% of the general population, is the most common cause of sudden cardiac death in young people. Hypertrophic cardiomyopathy (HCM) is a genetic disorder that is characterized by left ventricular hypertrophy unexplained by secondary causes and a nondilated left ventricle with preserved or increased ejection fraction. It mainly manifests as symmetric or asymmetric left ventricular hypertrophy (LVH) > 1.5 cm (Figure 23–1) in a nondilated ventricle unexplained by other cardiac or systemic causes of hypertrophy (see Table 23–1 for differential diagnosis of LVH). The mitral valve can also be affected and is unable to close properly. 1,2 It has a prevalence of 1 in 500 within the general population, and is a known cause of sudden cardiac death. Hypertrophic cardiomyopathy (HCM) is a condition in which the heart becomes thickened without an obvious cause. This results in the heart being less able to pump blood effectively and also may cause electrical conduction problems.. People who have HCM may have a range of symptoms. INTRODUCTION. However, unlike the type above, the thickened area causes an obstruction that affects the flow of blood leaving the heart. Looks like you’ve clipped this slide to already. The thickened heart muscle can make it harder for the heart to pump blood.Hypertrophic cardiomyopathy often goes undiagnosed because many people with the disease have few, if any, symptoms and can lead normal lives with no significant problems. presentations for free. Colors correspond to the Class of Recommendation No public clipboards found for this slide. Or use it to find and download high-quality how-to PowerPoint ppt presentations with illustrated or animated slides that will teach you how to do something new, also for free. Pathophysiology 3. A J Marian (Jan 1, p 58)1 postulates that cardiac contractility is decreased in hypertrophic cardiomyopathy (HCM) and that the preserved or increased ejection fraction observed in patients with HCM is a result of the concentric nature of the hypertrophy. Classification and Definitions of Cardiomyopathies 9 3.1. Primary cardiomyopathies 3.1.1 Genetic 3.1.1.1 Hypertrophic cardiomyopathy HCM is a condition of the heart in which a part of the myocardium or the muscle of the Hypertrophic cardiomyopathy (HCM) is a genetically determined heart muscle disease most often (60 to 70 percent) caused by mutations in one of several sarcomere genes which encode components of the contractile apparatus of the heart. HYPERTROPHIC. The two patients thought to be in cardiogenic shock were given inotropes … The ventricle size often remains normal, but the thickening may block blood flow out of the ventricle. And they’re ready for you to use in your PowerPoint presentations the moment you need them. Spirito, P. et al. Clinical aspect of myocardial Hypertrophic cardiomyopathy (HCM) is a genetically determined heart muscle disease most often (60 to 70 percent) caused by mutations in one of several sarcomere genes which encode components of the contractile apparatus of the heart. In other instances, the cause is unknown. Hypertrophic cardiomyopathy (HCM) is a genetic disorder that is characterized by left ventricular hypertrophy unexplained by secondary causes and a nondilated left ventricle with preserved or increased ejection fraction. What Causes Hypertrophic Cardiomyopathy? See our Privacy Policy and User Agreement for details. INHibition of the renin angiotensin system in hypertrophic cardiomyopathy and the Effect on hypertrophy, - INHibition of the renin angiotensin system in hypertrophic cardiomyopathy and the Effect on hypertrophy a Randomized Intervention Trial with losartan. The disease has complex symptomatology and potentially devastating consequences for … Hypertrophic Obstructive Cardiomyopathy (Case Presentation). Long-term athletic training can produce “athlete’s heart” = increased LV diastolic cavity dimensions/wall thickness/mass. Cardiomyopathy is any structural and functional abnormality of the heart muscle unattributable to specific causes or disease processes such as coronary artery disease (CAD), congenital heart disease, or valvular disease. Sudden cardiac death due to HCM-related causes is most prevalent in young African-American male athletes. - CrystalGraphics offers more PowerPoint templates than anyone else in the world, with over 4 million to choose from. Sato H, TateishiH, Uchida T, et al. It is commonly asymmetrical with the most severe hypertrophy involving the basal interventricular septum. It is commonly asymmetrical … Colors correspond to the Class of Recommendation Over the years, classification of this condition has been updated by the rapid advancement of genetic, imaging, and clinical investigation. Therapeutics market report provides a brief and detailed knowledge of key reports, market conditions circumstances... 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